Hepatitis B Vaccination in Singapore
Hepatitis B is a viral infection that affects the liver and can lead to severe complications, such as cirrhosis, liver failure and liver cancer, if left untreated. The Hep B virus spreads through contact with infected blood, semen, or other bodily fluids.
Hepatitis B virus (HBV) is the most common hepatitis virus in Singapore, and 6% of the local population are Hep B carriers. It is estimated that between 25-50% of these carriers may die prematurely, either as a result of chronic liver inflammation, liver failure (cirrhosis) or liver cancer.
Why Do You Need the Hepatitis B Vaccine?
Hepatitis B is a contagious virus that transmits through blood, semen, or bodily fluids. Hep B infection can lead to serious complications like chronic liver disease, cirrhosis, or even liver cancer. Protecting yourself with the Hepatitis B vaccine is not just about your health—it’s about safeguarding your family and the communities you love.
As part of Singapore’s National Childhood Immunisation Schedule (NCIS) and National Adult Immunisation Schedule (NAIS), this vaccine plays a vital role in ensuring the well-being of everyone, from little ones to adults.
By choosing vaccination, you’re taking a powerful step to protect yourself and the people closest to you, helping create a healthier, stronger community for generations.
Why is Hepatitis B Screening Important?
Hepatitis B is often asymptomatic in its early stages, making regular screenings essential to prevent long-term liver damage.
1
Detect active infections before symptoms appear
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Identify carriers who can unknowingly transmit the virus
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Protect high-risk groups, such as pregnant women, healthcare professionals, and those with a family history of the disease.
Our screenings are designed to empower you to take control of your health, ensuring timely interventions for better outcomes.
Types of Hep B Vaccines in Singapore
Monovalent Hepatitis B Vaccines: These vaccines target only the Hepatitis B virus and are administered in three doses over six months (Months 0, 1 and 6). They are suitable for individuals of all ages, including newborns, children, and adults. Common brands include Engerix-B and Recombivax HB.
Combination Vaccines: For added convenience, combination vaccines protect against Hepatitis B and other diseases:
- Hexavalent Vaccines: These six-in-one vaccines protect against diphtheria, tetanus, pertussis (whooping cough), poliomyelitis, Haemophilus influenzae type b, and Hepatitis B. They are commonly administered to infants as part of the National Childhood Immunisation Schedule (NCIS). An example is Infanrix hexa.
- Twinrix: This vaccine offers protection against both Hepatitis A and Hepatitis B, making it suitable for those who require immunisation against both viruses. It’s recommended for those travelling to regions where these infections are prevalent.
Our doctor will help determine the best vaccine schedule for you. You may also check with us if you are eligible for subsidised vaccinations under Singapore’s National Adult Immunisation Schedule (NAIS).
How the Hepatitis B (HepB) Vaccine Works
At Prologue, we utilise Engerix-B as a powerful tool for protecting against Hepatitis B infection. It contains inactivated HBV surface antigens—proteins derived from the virus that are harmless yet strong enough to activate your immune system.
Introducing the Hep B vaccine into your body stimulates an immune response, prompting your system to produce antibodies that target the Hepatitis B virus. These antibodies act as vigilant defenders, ready to neutralise or destroy the virus if it ever enters your body.
How Engerix-B helps:
- Prevents HBV infection, reducing the risk of liver damage and cancer.
- Triggers immune response for long-term protection.
- Given in 3 doses over 6 months for lasting immunity.
- Recommended for newborns, healthcare workers, and at-risk individuals.
By creating this long-lasting immunity, the Hepatitis B vaccine (Engerix-B) provides enduring protection, helping you safeguard your liver health and overall well-being.
What to Expect During a Hepatitis B Screening
We prioritise your comfort and provide a thorough screening process:

Initial Consultation
During your visit, our doctor will assess your medical history, lifestyle factors, and any symptoms or risk factors.

Blood Tests For
- HBsAg (Hepatitis B Surface Antigen): Indicates infection.
- Anti-HBs (Hepatitis B Antibodies): Indicates immunity from prior infection or vaccination.
- Liver Function Tests (LFTs): Detects liver inflammation or damage.

Personalised Guidance
After reviewing your results, we provide tailored recommendations for vaccinations, lifestyle changes and further management.
Who Should Get the Hep B Vaccine?
- Infants: Newborns should receive their first dose at birth, followed by additional doses at 1–2 months and 6–18 months.
- Children and Adolescents: Unvaccinated individuals under 18 should complete their doses as soon as possible.
- At-Risk Adults:
- Unvaccinated individuals
- Individuals with a Hepatitis B-infected partner
- Sexually active individuals not in monogamous relationships
- People who use injected drugs or share needles
- Individuals living with someone infected with Hepatitis B
- Healthcare and public safety workers exposed to blood or body fluids
- Travelers to regions with high Hepatitis B rates
- Individuals with chronic liver disease, kidney disease on dialysis, HIV, Hepatitis C, or diabetes
- Those seeking evaluation or treatment for STDs
- Victims of sexual assault or abuse
- Men who have sex with men
Population | Screening and Testing Recommendation |
---|---|
Adults with no known risk factors for Hepatitis B | If never previously screened, test for HBsAg and anti-HBs. |
With additional risk factors | Add on hepatitis C (anti-HBc) and A (anti-HAV) screening |
Treatment Options and Pricing for Hepatitis B
Hepatitis B vaccination at Prologue LMC costs $43. You may also choose to get vaccinated for Hepatitis A together at $121.80.
Get Vaccinated Today
Hepatitis B is preventable and manageable with early detection, and we’re here to guide you in protecting yourself and your loved ones.
As a CHAS and Healthier SG Clinic, we strive to make quality care accessible with subsidies that help lighten the load.
Contact us today to learn more or schedule an appointment—we’re here to safeguard your health and create a stress-free future for you and your loved ones.
FAQ
What is Hepatitis B?
A viral infection that lowers liver health, potentially causing severe complications if untreated.
How is Hepatitis B transmitted?
Through infected blood, bodily fluids, or mother-to-child transmission during childbirth.
Is the Hepatitis B vaccine mandatory?
It is not mandatory but highly recommended.
What are the symptoms of Hepatitis B?
Symptoms include fatigue, jaundice, nausea, and abdominal pain, though many remain asymptomatic.
Can Hepatitis B be cured?
While no cure exists, treatments can effectively manage the virus and prevent complications.
Who should get the Hep B vaccine?
Infants, unvaccinated children and adults, healthcare workers, and adults with high exposure risks.
How is the Hepatitis B Vaccine administered?
The Hep B vaccine is typically administered as an injection into the muscle, usually in the deltoid area (shoulder or upper arm).
Certain individuals with specific medical conditions, such as those undergoing haemodialysis or weakened immune systems, may require booster doses for continued protection.
What are the side effects of the vaccine?
It’s normal to experience mild side effects after vaccination, but monitoring your symptoms and knowing when to seek medical attention is vital. Here’s what to look out for:
Common Side Effects
- Pain, redness, bruising, or swelling at the injection site (use a cold compress for relief).
- Joint and muscle aches
- Mild fever, headache, dizziness, or fatigue (paracetamol can help; these symptoms usually resolve independently).
- Upper respiratory tract symptoms
- Nausea, vomiting, diarrhoea, abdominal pain
- Feeling irritable or faint (sit down for 15 minutes to avoid fainting).
Rare Side Effects
Seek immediate medical attention if you experience:
- Swollen face, eyes, lips, or tongue.
- Difficulty breathing.
- Pale skin or weakness.
- Itchy skin rashes or hives over the whole body.
- Fast heartbeat.
If any symptoms persist or worsen, seeing a doctor promptly is crucial.
Are there any precautions I should take?
Inform your doctor if you:
- Are allergic to any vaccine ingredients (e.g. yeast protein)
- Are pregnant, breastfeeding, or planning to conceive
- Have a weakened immune system or are undergoing treatment for conditions like cancer
- If you have a weakened immune system due to conditions like HIV/AIDS or cancer or are undergoing chemotherapy
- If you are currently on any medications, including over-the-counter drugs and supplements
- Are experiencing a fever, or are unwell
- Have a history of bleeding disorders
Can I take my Hepatitis B vaccine along with other vaccinations?
The Hepatitis B vaccine can be administered as a standalone injection or combined with the Hep A vaccine in a single shot.
How effective is the Hep B vaccine?
The Hepatitis B vaccine is highly effective in preventing infection. Studies show that immunity lasts at least 30 years in healthy individuals who begin Hep B vaccination within the first 6 months of life.
What subsidies are available for vaccinations?
As a CHAS and Healthier SG Clinic, we provide access to subsidies for eligible patients. Please check with our friendly staff for more information.