Lucence Cancer Screening
Lucence Cancer Screening, or LucenceINSIGHT™, is a simple blood test offered in Singapore that detects DNA fragments and other biological markers linked to certain cancers.
LucenceINSIGHT™ allows for early detection of cancer before any symptoms appear. enabling proactive health steps for higher success rates and improved treatment outcomes.
How Does Lucence Cancer Screening Assess Your Cancer Risk?
LucenceINSIGHT™ detects cancer signals in your blood by screening for multiple types of cancer using a multi-cancer early detection (MCED) method. This test analyses circulating tumour DNA (ctDNA) through a highly sensitive sequencing process that includes “mirror barcodes” to reduce errors. It identifies specific DNA changes related to cancer, such as single nucleotide variants, insertions, deletions, and certain types of viral DNA.
In clinical validation studies, LucenceINSIGHT™ demonstrated a detection limit as low as 0.05% for specific mutations, achieving 99% accuracy in detecting cancer markers with an overall sensitivity of 80.9%. Additionally, it can predict the potential tissue of origin for up to 21 cancer types with an accuracy of 87.7%, helping provide a focused understanding of your cancer risk.
How Markers Are Linked to Various Types of Cancer
LucenceINSIGHT™ identifies markers linked to various types of cancer by detecting specific changes in the DNA found in your blood. These markers are indicators of potential cancer risks, offering insights into early signs of cancer. The test also detects viral DNA, such as HPV-related DNA, which can be associated with certain cancers like head and neck cancers. By identifying both genetic markers and viral DNA, LucenceINSIGHT™ provides a more complete picture of your cancer risk, enabling earlier intervention and more informed decisions about your health.
Recent studies presented at ASCO 2023 and ESMO Asia 2023 show how effective LucenceINSIGHT™ can be. One study, involving over 1,400 patients, demonstrated its high sensitivity and ability to spot cancers that are often missed by traditional screening methods. The research highlighted how the test’s precision can make a real difference in detecting cancer earlier, improving the chances of successful intervention.
Limitations of Tumour Marker Tests
1
High False Positives
Many individuals experience false positives over time, with nearly 40% receiving at least one false positive result within five years. This can lead to unnecessary anxiety and additional testing.
2
Limited Specificity
Protein markers often lack specificity, with accuracy levels falling below 90%, making it challenging to distinguish cancer from other conditions.
3
Elevated Markers in Non-Cancerous Conditions
Certain tumour markers can be raised due to non-cancerous health issues, causing potential misdiagnoses or confusion.
4
Need for invasive follow-ups
False positives or unclear results often require additional invasive procedures, such as biopsies or imaging, to confirm or rule out a cancer diagnosis.
Examples of Protein Markers and Their Limitations
Protein markers like CA15-3, CA-125, CEA, PSA, and b-HCG are generally used to monitor response to cancer treatment and to screen for recurrence of certain cancers. However, these markers can also be higher in other health conditions that aren’t related to cancer, which can cause confusion.
For example, CA15-3, which is mostly linked to breast cancer, can also be raised in conditions like benign ovarian problems, other breast issues, or liver disease. Similarly, CA-125, a marker for ovarian cancer, can be higher due to other gynaecological problems or inflammation.
CEA, used for colorectal cancer, can also increase in people who smoke or have conditions like ulcerative colitis or liver problems. PSA, a marker for prostate cancer, can be affected by non-cancerous issues like an enlarged prostate, aging, or even activities like cycling or ejaculation.
Finally, b-HCG, which is used for detecting germ cell tumours, can also be raised in situations like pregnancy, marijuana use, or certain hormonal issues. Because of these overlaps, these markers aren’t always reliable for diagnosing cancer and can sometimes lead to unnecessary tests or procedures.
Benefits of Lucence Cancer Screening
Unlike regular blood tests or full blood count tests, LucenceINSIGHT™ focuses specifically on cancer markers instead of general health indicators. This test identifies DNA changes related to cancer in your bloodstream and predicts the tissue of origin for up to 21 types of cancer with 88% accuracy.
Early Risk Assessment
LucenceINSIGHT™ provides an early look at your cancer risk through marker analysis, without diagnosing cancer.
Comprehensive Screening
It detects markers for 50 different types of cancer from various organs, including cancers that traditional screenings may miss.
Simple Process
It only requires a single blood test, instead of more invasive procedures like mammograms, colonoscopies, or Pap tests.
Sample Requirements
Only two blood tubes (18mL) are needed, along with a completed order form and consent from both you and your physician. No fasting is required for the test. However, it’s recommended to avoid heavy meals at least 4 hours before your blood sample collection.
High Accuracy
LucenceINSIGHT™ uses advanced technology with 99% specificity in detecting cancer markers, ensuring reliable results.
Quick Turnaround
Results are available within 12 to 18 working days, offering timely insights for you to take the next steps.
Key Considerations for Lucence Cancer Screening
- Cancer Signal Detection, Not Diagnosis
LucenceINSIGHT™ looks for signs that might suggest cancer but doesn’t directly diagnose it. If the test shows a potential issue, further tests by your doctor are needed to confirm if cancer is present. - Not a Genetic Risk Test
This test doesn’t look at whether you might inherit a higher risk of cancer from your family. It focuses on detecting current signs of cancer in your body. - Supplementary to Standard Screening
LucenceINSIGHT™ should be used in addition to other regular cancer screenings your doctor recommends, not as a replacement for them. - Possibility of False Positives or Negatives
The test may sometimes show a result that isn’t accurate—either suggesting cancer when there isn’t any (false positive) or missing cancer that’s actually present (false negative). - Specific Cancer Coverage
LucenceINSIGHT™ only tests for the cancers included in its list. It doesn’t rule out the possibility of other types of cancer that aren’t included in the test. - Suitability
The test is not suitable for you if you have been recently diagnosed with cancer. It’s designed for individuals who have been cancer-free for at least three years.
How much is Lucence Cancer Screening in Singapore?
Lucence Cancer Screening is available at Prologue The Lifestyle Medical Clinic, with pricing depending on the type of test selected.
FAQ
How does cancer occur?
Cancer starts when the body’s cells begin to grow uncontrollably. Normally, cells grow, divide and die in an orderly way. However, when certain genes (which control cell growth and death) become damaged, they may cause cells to grow out of control. These abnormal cells can form a mass called a tumour. Some tumours can spread to other parts of the body, which is called metastasis. Various factors like genetics, lifestyle (such as smoking or poor diet) and environmental exposures can contribute to these genetic changes and increase cancer risk.
Can LucenceINSIGHT™ replace my current screening routine?
LucenceINSIGHT™ is a helpful screening tool, but it is not intended to replace your regular screenings (such as mammograms, colonoscopies, or Pap smears). It’s an additional test that can detect early signs of cancer by identifying specific markers in your blood. It’s best to use LucenceINSIGHT™ alongside other recommended screenings for a more complete picture of your health. Always consult your healthcare provider to understand which tests are right for you.
Who has access to my results?
Your LucenceINSIGHT™ results are confidential and will only be shared with the healthcare provider you choose. This ensures that your doctor can review the results with you and discuss any next steps or follow-up actions. You have the right to decide who gets to see your test results, and your privacy is protected under medical confidentiality laws.
Where can I get tested for LucenceINSIGHT™ in Singapore?
LucenceINSIGHT™ is available at Lifestyle Medical Clinic in Singapore. To get tested, you will first need to consult with a healthcare provider at the clinic. The provider will assess your health and determine if the test is suitable for you, then they will order it on your behalf. After the test is ordered, you can have it done directly at the clinic. This step ensures that the test is ordered based on professional advice and that your results are properly interpreted. For more information or to schedule your screening, visit Lifestyle Medical Clinic.
How often should I get screened?
The frequency of screening depends on your personal health risk factors and age. For individuals aged 40 and above, or those with higher cancer risks (like a family history of cancer), it’s a good idea to consider regular screenings. Typically, healthcare providers might recommend screening every 1-2 years, but this can vary. It’s best to follow the guidance of your healthcare provider to determine how often you should get screened based on your individual health status.
What if I receive a positive result on LucenceINSIGHT™?
The frequency of screening depends on your personal health risk factors and age. For individuals aged 40 and above, or those with higher cancer risks (like a family history of cancer), it’s a good idea to consider regular screenings. Typically, healthcare providers might recommend screening every 1-2 years, but this can vary. It’s best to follow the guidance of your healthcare provider to determine how often you should get screened based on your individual health status.
What is clonal hematopoiesis?
Clonal hematopoiesis refers to a condition where a group of blood cells (or a “clone”) grows from a single mutated stem cell. This can happen naturally as we age, but sometimes the mutations can increase the risk of developing blood cancers, such as leukemia. While clonal hematopoiesis is common, most people with this condition will not develop cancer. However, it may show up as part of genetic testing like LucenceINSIGHT™. If detected, your healthcare provider may recommend additional monitoring or follow-up to assess your health risk.
Can you live with cancer for years?
Yes, it is possible to live with cancer for years, especially if it’s detected early and managed properly. Advances in cancer treatment have improved survival rates, and some cancers can be controlled or treated effectively, allowing people to live for many years after diagnosis. The length of time someone can live with cancer depends on factors like the type of cancer, how early it’s detected, the stage of the disease, the effectiveness of treatments, and overall health. Regular monitoring and treatment can often help manage the disease and improve quality of life.
